Poster Presentation Clinical Oncology Society of Australia Annual Scientific Meeting 2018

Changes in colorectal cancer (CRC) presentation over a 10 year period (2005-2016) in South Western Sydney Local Health District (SWSLHD) : results from a clinicopathological database (#167)

Sarah Maloney 1 , Kate Wilkinson 1 , Hiren Mandaliya 2 , Stephanie Lim 2 , Aflah Roohullah 1 , Annette Tognela 1 , Ray Asghari 3 , Weng Ng 1 , Soon Lee 4 , Wei Chua 1
  1. Medical Oncology, Liverpool Cancer Therapy Centre, Sydney, NSW, Australia
  2. Medical Oncology, MacArthur Cancer Centre, Sydney, NSW, Australia
  3. Medical Oncology, Bankstown Cancer Therapy Centre, Bankstown, NSW, Australia
  4. Pathology, Liverpool Hospital, Sydney, NSW, Australia


Colorectal cancer is the third most diagnosed cancer in Australia and the second leading cause of cancer death(1). SWSLHD is one of the largest health districts in NSW serving a population of almost 1 million people. The patterns of colon cancer (CC) presentation in this diverse population including changes over time may have implications for health service provision and public health campaigns.



A retrospective review of patients who underwent primary tumour resection (PTR) and histopathology review for CC in SWSLHD from 2006-2015 with clinicopathological data were included. Basic demographics, site and stage of presentation, systemic therapy used, and recurrent/ survival data were collected in addition to tumour pathology data. Patients were analysed in two separate 5-year cohorts between 2006-2010 and 2011-2015 and chi-square tests were performed for categorical variables.



907 patients were identified between 2006-2015 (329 between 2006-2010 and 578 between 2011-2015). Median age of diagnosis was 70 in both 5-year cohorts, predominantly male (51%) and of Caucasian (87%) or Asian ethnicity (12%. In this cohort receiving PTR, for the 2006-2010 cohort, 55% presented with early stage (1,2) CC and 45% late stage (3,4) CC and between 2011-2015, 52% and 48% had early and late stages respectively, with no statistically significant difference in stage over time (p= 0.28). There was a statistically significant difference in colon cancer sidedness of presentation with more patients diagnosed with right (71%) rather then left sided (29%) cancer between 2011 -2015 compared to 2006 - 2010 (64% right and 36% left) (p value <0.028).



There was no statistical significance difference in age of diagnosis, gender, ethnicity or stages of presentation between the two 5-year cohorts. In the 2011-2015 cohort, more patients presented with right-sided CC compared to 2006-2010.  These results require further exploration including correlation with molecular pathology and clinical outcomes and may inform future screening and treatment strategies.

  1. 1. Welfare, Australian Institute of Health and. Australia Cancer Incidence and Mortality (ACIM) books. Canberra : AIHW.